Current Research Projects

Pathogenesis of ovine betaretroviruses

The study of oncogenic retroviruses has been instrumental in elucidating the functions of key cellular proteins involved in cell growth and transformation. Many of the oncogenes found to be active in human cancers were first discovered in avian, murine and feline retroviruses. Moreover, the discovery of the activation of cellular genes upon retroviral insertion into […]

Oncolytic virotherapy using Newcastle disease virus and parapox ORF virus

Newcastle disease virus (NDV) is a member of the Avulavirus genus in the Paramyxoviridae family. NDV selectively replicates in tumor cells due to defects in antiviral and apoptotic signalling. NDV has the longest history of use in clinical trials of all oncolytic viruses and has a proven safety record as a monotherapy due to its […]

Antibody-based protection against Ebola virus infection by vectored immunoprophylaxis

Pathogens for which the human population has no pre-existing or vaccine-induced immunity and which pose a significant threat to public health, require rapid and cost effective countermeasures to block transmission and mitigate disease. One such method that has proven successful is the administration of neutralizing antibodies to patients as a means of pre- and post-exposure […]

Development of a recombinant parapoxvirus vaccine to protect against Toxoplasma gondii infection in sheep

Live virus vaccines are excellent inducers of long-term immunity by eliciting protective humoral and cell-mediated immune responses against foreign antigens. To this end, recombinant poxviruses are one of the most versatile expression systems for foreign antigens and have been extensively developed as vaccine vectors for veterinary diseases. Recently, the type species ORFV (ORFV) of the […]